2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-CE01038
    3-Hydroxyhexanoyl-CoA 74875-70-0
    3-Hydroxyhexanoyl-CoA (3-Hydroxyhexanoyl-coenzyme A) is a derivative of coenzyme A.
    3-Hydroxyhexanoyl-CoA
  • HY-CE02017
    trans-Feruloyl-CoA 142185-30-6
    trans-Feruloyl-CoA (trans-Feruloyl-coenzyme A) is a derivative of coenzyme A. trans-Feruloyl-CoA also acts as an activated acyl donor involved in the synthesis of cell wall components such as lignin and feruloylated polysaccharides.
    trans-Feruloyl-CoA
  • HY-D18569F
    3-Indoleacetic acid, biotin labeled 98%
    3-Indoleacetic acid, biotin labeled the biotin labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid, biotin labeled can be conjugated to streptavidin for purification.
    3-Indoleacetic acid, biotin labeled
  • HY-N0111S2
    Coenzyme Q10-d9 2687960-97-8 98.52%
    Coenzyme Q10-d9 is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10-d9
  • HY-N0229S4
    L-Alanine-13C,d1 160033-81-8 98.0%
    L-Alanine-13C,d is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-13C,d1
  • HY-N0378S1
    D-Mannitol-13C 132202-29-0 99.9%
    D-Mannitol-13C is the 13C labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
    D-Mannitol-13C
  • HY-N0378S2
    D-Mannitol-13C6 287112-34-9 98.0%
    D-Mannitol-13C6 is the 13C labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
    D-Mannitol-13C6
  • HY-N0486S6
    L-Leucine-2-13C,15N 285977-88-0 98.0%
    L-Leucine-2-13C,15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-2-13C,15N
  • HY-N1446BR
    Oleic acid sodium (Standard) 143-19-1
    Sodium oleate (Standard) is the analytical standard of Sodium oleate. This product is intended for research and analytical applications. Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].
    Oleic acid sodium (Standard)
  • HY-N1902S1
    4-Hydroxyphenylacetic acid-d4 98.75%
    4-Hydroxyphenylacetic acid-d4 is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2.
    4-Hydroxyphenylacetic acid-d4
  • HY-P10380A
    palm11-PrRP31 TFA 99.44%
    palm11-PrRP31 TFA is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 TFA is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 TFA is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 TFA can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction.
    palm11-PrRP31 TFA
  • HY-P10697A
    VH4127 TFA
    VH4127 TFA is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a KD of 18 nM for hLDLR. VH4127 TFA specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR.
    VH4127 TFA
  • HY-P10927A
    BRP TFA 98%
    BRP (BRINP2-related peptide) TFA is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP TFA induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP TFA exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP TFA is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP TFA is applicable to obesity-related research.
    BRP TFA
  • HY-P11578A
    CKGGRAKDC (linear) TFA
    CKGGRAKDC (linear) TFA is an adipose tissue homing peptide. CKGGRAKDC (linear) TFA binds to vasculature-enriched prohibitin in adipose tissue to enable selective tissue targeting. CKGGRAKDC (linear) TFA can be used to selective delivery of cargos to adipose tissues.
    CKGGRAKDC (linear) TFA
  • HY-P60234A
    AGFAGDDAPR 330204-04-1 98%
    AGFAGDDAPR is a bioactive peptide that is a competitive and orally effective inhibitor of dipeptidyl peptidase-IV (DPP-IV). AGFAGDDAPR can enhance the level of GLP-1 in the body by inhibiting DPP-IV, thereby stimulating insulin secretion, improving β-cell function, and inhibiting abnormal proliferation of α-cells, exerting anti-diabetic effects. AGFAGDDAPR can be used for research on type 2 diabetes.
    AGFAGDDAPR
  • HY-W008356
    2-Fluoro-4-iodobenzonitrile 137553-42-5 99.97%
    2-Fluoro-4-iodobenzonitrile is a building block, which can be used to synthesize L. infantum trypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors. 2-Fluoro-4-iodo benzonitrile can also be used to synthesize transient receptor potential ankyrin 1 (TRPA1) antagonists.
    2-Fluoro-4-iodobenzonitrile
  • HY-W010476
    2,3,5-Trimethylpyrazine 14667-55-1 99.92%
    2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine
  • HY-W011249
    Phosphorylcholine chloride calcium salt tetrahydrate 72556-74-2 98.0%
    Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.
    Phosphorylcholine chloride calcium salt tetrahydrate
  • HY-W012583
    2,2'-Thiodiacetic acid 123-93-3 ≥98.0%
    2,2'-Thiodiacetic acid (Thiodiglycolic acid) is a human L-xylulose reductase (XR) inhibitor with inhibition rate of 28% at 10 mM. 2,2'-Thiodiacetic acid can be used for the research of diabetes .
    2,2'-Thiodiacetic acid
  • HY-W015786
    4-Ethoxyphenol 622-62-8 99.86%
    4-Ethoxyphenol is a natural compound isolated from marine gorgonian-associated bacterium Bacillus amyloliquefaciens SCSIO 00856. 4-Ethoxyphenol shows potent antilarval activity towards Bacillus amphitrite larvae with an EC50 value of 24.1 μg/mL.
    4-Ethoxyphenol
Cat. No. Product Name / Synonyms Application Reactivity